3. Laser assisted hatching in good prognosis patients undergoing in vitro fertilization-embryo transfer
This prospective randomized controlled trial was conducted to evaluate whether assisted hatching improves clinical outcomes of embryo transfers to good prognosis patients, defined as patients < or =39 years with normal follicle-stimulating hormone (FSH) and E(2) levels, no more than one previous unsuccessful cycle of in vitro fertilization (IVF)-embryo transfer, and good embryo quality The study comprised one hundred ninety-nine good prognosis patients undergoing IVF-embryo transfer on day 3 after oocyte retrieval with or without assisted hatching using a 1,480-nm wavelength infrared laser. Clinical intrauterine pregnancy, spontaneous pregnancy loss, and live birth were the main outcome measures.. Rates of clinical intrauterine pregnancy with fetal cardiac activity (53% vs. 54% per cycle), spontaneous pregnancy loss (13% vs. 16% per pregnancy), and live birth (47% vs. 46% per cycle) were very similar between treatment cycles with laser-assisted hatching and control cycles in which embryos were transferred without assisted hatching. There were no significant differences between treatment and control groups in any measured clinical outcome parameters. Assisted hatching does not improve clinical outcomes among good prognosis patients.
Sagoskin AW, Levy MJ, Tucker MJ, Richter KS, Widra EA Laser assisted hatching in good prognosis patients undergoing in vitro fertilization-embryo transfer: a randomized controlled trial. Fertil Steril. 2007 Feb;87(2):283-7. Epub 2006 Nov 13.
4. Bed rest after embryo transfer: a randomized controlled trial.
This randomized controlled study was conducted to determine whether bed rest after embryo transfer leads to improved pregnancy rates The study included patients undergoing 164 cycles of IVF and were randomized to 30 minutes of bed rest after embryo transfer or immediate discharge from the clinic. Clinical PR defined by visualized fetal heart beat and ongoing PR defined by viable intrauterine gestation beyond 11 weeks were the main outcome measures. The clinical and ongoing PR for both groups were 50% and 46.3%, respectively, with no statistically significant difference between the two groups. It is concluded that thirty minutes of bed rest after embryo transfer does not improve PR.
Purcell KJ, Schembri M, Telles TL, Fujimoto VY, Cedars MI. Bed rest after embryo transfer: a randomized controlled trial.
Fertil Steril. 2007 Jun;87(6):1322-6. Epub 2007 Mar 23.